呂宥萱 Yu-Hsuan Lu

Educated in the Post-Baccalaureate Medicine at Kaohsiung Medical University, followed by comprehensive ophthalmology residency training at Hualien Tzu Chi Hospital, and now practicing at Nobel Eye Clinic. A professional path grounded in disciplined training, clinical precision, and a commitment to patient-centered care. Advanced expertise in refractive surgery, supported by formal certifications in SMILE by ZEISS, and SILK by J&J. Clinical practice also spans childhood myopia control, femtosecond laser–assisted cataract surgery, and comprehensive dry eye management. Care shaped by clarity, patience, and calm confidence—ensuring each patient feels understood, informed, and reassured throughout their treatment. Continuous refinement through innovation and evidence-based practice, integrating the latest techniques to elevate visual outcomes and overall comfort. A career defined by thoughtful judgment, refined skill, and a sincere dedication to helping patients experience clearer, more comfortable vision.

Day 1 Saturday - 13 Dec 2025

Time	Session

08:30 12:00	屈光手術 Wet Lab Lecture \| Refractive Wet Lab Instruction Course ZH 屈光手術 Wet Lab Lecture \| Refractive Wet Lab Instruction Course 張朝凱 Chao-Kai ChangTaiwan Moderator 馬惠康 David Hui-Kang MaTaiwan Moderator Cultivated Oral/Nasal Mucosal Epithelial Sheets for Ocular Surface Reconstruction in TaiwanBackground To investigate the in vivo epithelial phenotypes of cultivated nasal mucosal epithelial cell (CUNMEC) sheets generated by a microspheroidal suspension culture technique. Methods Human nasal mucosal tissues were obtained during DCR. The tissues were digested with 2 mg/mL collagenase A, then the cell aggregates were seeded onto a de-epithelialized AM and cultivated for 2 weeks. The CUNMEC sheets were then transplanted into New Zealand albino rabbits. The animals were subjected to immunosuppression for two weeks and then sacrificed. The samples were subjected to light and electron microscopy (EM) and immunoconfocal microscopy examinations. Results The presence of CUNMECs in rabbit eyes was confirmed by anti-human cytoplasmic antibody staining. Keratins 3, 4, and 13 were positively expressed in the suprabasal region, whereas p63 expression was observed only in the basal layer. Transmission EM revealed stratified epithelium with the formation of desmosomes and hemidesmosomes. Scanning EM revealed a cobble stone-like epithelial surface without cilia formation. α-Tubulin, a major component of cilia, was expressed only in the apical region of the nasal mucosa and showed diffuse cytoplasmic staining in the CUNMEC sheets. ZO-1, a component of tight junctions, was expressed in the apical region of the nasal mucosa and was expressed at intercellular borders in CUNMECs. Conclusion Following transplantation, the CUNMEC sheet presented a stratified epithelial layer containing GCs but without cilia and expressed progenitor cell markers, which are morphologically similar to those of ocular surface epithelia and may have the potential to function as a surrogate epithelium for ocular surface reconstruction, especially in dry eye conditions. Opening Innovation in KLEx Surgery 呂宥萱 Yu-Hsuan LuTaiwan Speaker Innovation in KLEx SurgeryKeratorefractive Lenticule Extraction (KLEx) continues to evolve as a leading minimally invasive approach for corneal refractive correction. Among emerging technologies, Johnson & Johnson Vision’s Smooth Incision Lenticule Keratomileusis (SILK) represents a significant advancement within the KLEx family by addressing key limitations of earlier lenticule-based procedures. SILK is engineered around three core innovations: exceptionally low pulse energy, smooth continuous dissection, and a biconvex lenticule design. SILK operates at an ultralow pulse energy of approximately 50 nJ, one of the lowest among current refractive laser platforms. This reduced energy delivery minimizes collateral stromal disruption, promotes cleaner interface quality, and may decrease postoperative inflammation. Complementing this, SILK utilizes a smooth, continuous dissection pattern that creates highly uniform cleavage planes. This design facilitates gentle lenticule separation and extraction through a micro-incision, reducing mechanical stress on the cornea and supporting rapid early visual recovery. A further distinguishing feature is the biconvex lenticule configuration, which improves its natural conformability to the stromal bed and reduces interface mismatch. This enhanced anatomical fit may help preserve subbasal corneal nerves during tissue creation and extraction, thereby lowering the risk of postoperative dry eye symptoms and supporting overall ocular surface health. Together, these innovations position SILK as a refined next-generation KLEx technique with strong potential in clinical practice. Ongoing investigations comparing the strengths and limitations of different KLEx approaches will continue to guide technique optimization, with the ultimate goal of providing patients with the safest and most effective refractive surgical outcomes. KLEx Surgery Procedure & Tips 歐又齊 You-Ci OuTaiwan Speaker KLEx Surgery Procedure & TipsKLEx surgery mainly includes procedures such as SMILE, SMILE Pro, and SILK. In essence, these surgical techniques are quite similar. However, to further reduce surgical time and enhance patient comfort and satisfaction, we can incorporate certain refinements and add small but effective techniques to our own surgical workflow. In this discussion, I will share some of my personal experiences before, during, and after surgery—specifically, how I optimize each step to achieve a smoother procedure and better postoperative outcomes. Prepared and Ready For Your First Refractive Surgery 陳南妮 Nan-Ni ChenTaiwan Speaker Prepared and Ready for Your First Refractive SurgeryEvidence-based recommendations for KLEx in clinical practice -preoperative screening for keratoconus -surgical planning -management and prevention of complications and infection. Q&A 屈光手術 Wet Lab Lecture (Refractive Wet Lab Instruction Course) 孫啟欽 Chi-Chin SunTaiwan Moderator 馬惠康 David Hui-Kang MaTaiwan Moderator Cultivated Oral/Nasal Mucosal Epithelial Sheets for Ocular Surface Reconstruction in TaiwanBackground To investigate the in vivo epithelial phenotypes of cultivated nasal mucosal epithelial cell (CUNMEC) sheets generated by a microspheroidal suspension culture technique. Methods Human nasal mucosal tissues were obtained during DCR. The tissues were digested with 2 mg/mL collagenase A, then the cell aggregates were seeded onto a de-epithelialized AM and cultivated for 2 weeks. The CUNMEC sheets were then transplanted into New Zealand albino rabbits. The animals were subjected to immunosuppression for two weeks and then sacrificed. The samples were subjected to light and electron microscopy (EM) and immunoconfocal microscopy examinations. Results The presence of CUNMECs in rabbit eyes was confirmed by anti-human cytoplasmic antibody staining. Keratins 3, 4, and 13 were positively expressed in the suprabasal region, whereas p63 expression was observed only in the basal layer. Transmission EM revealed stratified epithelium with the formation of desmosomes and hemidesmosomes. Scanning EM revealed a cobble stone-like epithelial surface without cilia formation. α-Tubulin, a major component of cilia, was expressed only in the apical region of the nasal mucosa and showed diffuse cytoplasmic staining in the CUNMEC sheets. ZO-1, a component of tight junctions, was expressed in the apical region of the nasal mucosa and was expressed at intercellular borders in CUNMECs. Conclusion Following transplantation, the CUNMEC sheet presented a stratified epithelial layer containing GCs but without cilia and expressed progenitor cell markers, which are morphologically similar to those of ocular surface epithelia and may have the potential to function as a surrogate epithelium for ocular surface reconstruction, especially in dry eye conditions. Opening From Preoperative Findings to Procedure Choice: A Practical Overivew of Corneal and Intraocular Refractive Surgery 萬懿 Yi WanTaiwan Speaker From Preoperative Findings to Procedure Choice: A Practical Overivew of Corneal and Intraocular Refractive SurgeryThe outcome of refractive surgery is closely tied to how well patients are evaluated before surgery. This talk will give a practical overview of how preoperative findings help guide the choice between corneal and intraocular refractive procedures, drawing on the insights from recent literature. Topics include ocular surface condition, corneal biomechanics, and optical quality. Special attention will be given to findings that may limit certain procedures, such as severe dry eye, corneal dystrophy or degeneration, significant high-order aberrations, unstable biomechanics, nystagmus, previous enhancement, systemic disease, and large angle kappa. Age, refractive range, and lifestyle factors also play a role in deciding between corneal laser surgery and intraocular options like phakic or pseudophakic IOLs. The aim is to share a clear, clinically useful approach for safer and more individualized refractive surgery planning. Intra OP & Post OP Complication Management in Corneal Refractive Surgery 陳弘誌 Hung-Chih ChenTaiwan Speaker Intra OP & Post OP Complication Management in Corneal Refractive SurgeryCorneal refractive surgery has evolved significantly with modern laser platforms, diagnostic technologies, and surgical techniques, offering high safety, predictability, and patient satisfaction. Despite advancements, intraoperative and postoperative complications remain critical determinants of visual outcomes, warranting prompt recognition and evidence-based management. This review highlights key complication profiles and practical strategies for optimized peri-operative care in refractive procedures, including PRK, LASIK and KLEx. Intra-OP complications in corneal laser surgery primarily involve flap-related issues in LASIK (incomplete, irregular, free, or displaced flaps), docking or suction loss in femtosecond platforms, and interface problems. In KLEx, challenges include suction loss, black spots, cap perforation, retained lenticule fragments, incision tearing, and extraction difficulty. Immediate management strategies emphasize maintaining tissue integrity, minimizing further manipulation, and appropriate surgical abort or conversion when indicated. Post-OP adverse events may include dry eye disease, epithelial ingrowth, diffuse lamellar keratitis (DLK), infection, corneal haze, ectasia, residual refractive error, night vision disturbances, and elevated intraocular pressure. Management requires a tailored approach, such as aggressive lubrication and anti-inflammation support for ocular surface disease, early steroid escalation for haze and DLK, interface washout for progressive ingrowth, corneal cross-linking for biomechanical instability, and enhancement surgery when refractive targets are unmet. Regular monitoring via corneal tomography, epithelial mapping, and wavefront analysis aids early detection and intervention. A structured management algorithm, proactive risk assessment, surgeon experience, and patient-specific optimization remain essential to achieving safe, sustainable refractive outcomes and minimizing long-term morbidity. Preoperative Tomographic and Biomechanical Corneal Assessment for Refractive Surgery 胡鴻琳 Hung-Ling HuTaiwan Speaker Preoperative Tomographic and Biomechanical Corneal Assessment for Refractive SurgerySummary Appropriate patient selection remains fundamental to safe refractive laser surgery. Corneal tomography and corneal biomechanics are central to identifying early ectatic changes and biomechanical vulnerability. Tomography offers a 3-dimensional assessment of anterior and posterior corneal surfaces, enabling detection of subtle keratoconus and other contraindications. Key parameters such as posterior elevation patterns and pachymetric distribution help quantify ectasia risk. Corneal biomechanics, assessed with technologies like the Corvis ST or ORA, provide direct measurements of tissue stability. Metrics including deformation amplitude and corneal stiffness can uncover susceptibility to postoperative ectasia, even when tomography findings are within normal limits. Integrating both modalities improves preoperative risk stratification, enhances surgical safety, and supports more individualized refractive planning. Q&A 702

Time

Session

08:30

12:00

屈光手術 Wet Lab Lecture | Refractive Wet Lab Instruction Course

屈光手術 Wet Lab Lecture | Refractive Wet Lab Instruction Course

張朝凱 Chao-Kai ChangTaiwan Moderator

馬惠康 David Hui-Kang MaTaiwan Moderator Cultivated Oral/Nasal Mucosal Epithelial Sheets for Ocular Surface Reconstruction in TaiwanBackground To investigate the in vivo epithelial phenotypes of cultivated nasal mucosal epithelial cell (CUNMEC) sheets generated by a microspheroidal suspension culture technique. Methods Human nasal mucosal tissues were obtained during DCR. The tissues were digested with 2 mg/mL collagenase A, then the cell aggregates were seeded onto a de-epithelialized AM and cultivated for 2 weeks. The CUNMEC sheets were then transplanted into New Zealand albino rabbits. The animals were subjected to immunosuppression for two weeks and then sacrificed. The samples were subjected to light and electron microscopy (EM) and immunoconfocal microscopy examinations. Results The presence of CUNMECs in rabbit eyes was confirmed by anti-human cytoplasmic antibody staining. Keratins 3, 4, and 13 were positively expressed in the suprabasal region, whereas p63 expression was observed only in the basal layer. Transmission EM revealed stratified epithelium with the formation of desmosomes and hemidesmosomes. Scanning EM revealed a cobble stone-like epithelial surface without cilia formation. α-Tubulin, a major component of cilia, was expressed only in the apical region of the nasal mucosa and showed diffuse cytoplasmic staining in the CUNMEC sheets. ZO-1, a component of tight junctions, was expressed in the apical region of the nasal mucosa and was expressed at intercellular borders in CUNMECs. Conclusion Following transplantation, the CUNMEC sheet presented a stratified epithelial layer containing GCs but without cilia and expressed progenitor cell markers, which are morphologically similar to those of ocular surface epithelia and may have the potential to function as a surrogate epithelium for ocular surface reconstruction, especially in dry eye conditions.
Opening
Innovation in KLEx Surgery

呂宥萱 Yu-Hsuan LuTaiwan Speaker Innovation in KLEx SurgeryKeratorefractive Lenticule Extraction (KLEx) continues to evolve as a leading minimally invasive approach for corneal refractive correction. Among emerging technologies, Johnson & Johnson Vision’s Smooth Incision Lenticule Keratomileusis (SILK) represents a significant advancement within the KLEx family by addressing key limitations of earlier lenticule-based procedures. SILK is engineered around three core innovations: exceptionally low pulse energy, smooth continuous dissection, and a biconvex lenticule design. SILK operates at an ultralow pulse energy of approximately 50 nJ, one of the lowest among current refractive laser platforms. This reduced energy delivery minimizes collateral stromal disruption, promotes cleaner interface quality, and may decrease postoperative inflammation. Complementing this, SILK utilizes a smooth, continuous dissection pattern that creates highly uniform cleavage planes. This design facilitates gentle lenticule separation and extraction through a micro-incision, reducing mechanical stress on the cornea and supporting rapid early visual recovery. A further distinguishing feature is the biconvex lenticule configuration, which improves its natural conformability to the stromal bed and reduces interface mismatch. This enhanced anatomical fit may help preserve subbasal corneal nerves during tissue creation and extraction, thereby lowering the risk of postoperative dry eye symptoms and supporting overall ocular surface health. Together, these innovations position SILK as a refined next-generation KLEx technique with strong potential in clinical practice. Ongoing investigations comparing the strengths and limitations of different KLEx approaches will continue to guide technique optimization, with the ultimate goal of providing patients with the safest and most effective refractive surgical outcomes.
KLEx Surgery Procedure & Tips

歐又齊 You-Ci OuTaiwan Speaker KLEx Surgery Procedure & TipsKLEx surgery mainly includes procedures such as SMILE, SMILE Pro, and SILK. In essence, these surgical techniques are quite similar. However, to further reduce surgical time and enhance patient comfort and satisfaction, we can incorporate certain refinements and add small but effective techniques to our own surgical workflow. In this discussion, I will share some of my personal experiences before, during, and after surgery—specifically, how I optimize each step to achieve a smoother procedure and better postoperative outcomes.
Prepared and Ready For Your First Refractive Surgery

陳南妮 Nan-Ni ChenTaiwan Speaker Prepared and Ready for Your First Refractive SurgeryEvidence-based recommendations for KLEx in clinical practice -preoperative screening for keratoconus -surgical planning -management and prevention of complications and infection.
Q&A
屈光手術 Wet Lab Lecture (Refractive Wet Lab Instruction Course)

孫啟欽 Chi-Chin SunTaiwan Moderator

馬惠康 David Hui-Kang MaTaiwan Moderator Cultivated Oral/Nasal Mucosal Epithelial Sheets for Ocular Surface Reconstruction in TaiwanBackground To investigate the in vivo epithelial phenotypes of cultivated nasal mucosal epithelial cell (CUNMEC) sheets generated by a microspheroidal suspension culture technique. Methods Human nasal mucosal tissues were obtained during DCR. The tissues were digested with 2 mg/mL collagenase A, then the cell aggregates were seeded onto a de-epithelialized AM and cultivated for 2 weeks. The CUNMEC sheets were then transplanted into New Zealand albino rabbits. The animals were subjected to immunosuppression for two weeks and then sacrificed. The samples were subjected to light and electron microscopy (EM) and immunoconfocal microscopy examinations. Results The presence of CUNMECs in rabbit eyes was confirmed by anti-human cytoplasmic antibody staining. Keratins 3, 4, and 13 were positively expressed in the suprabasal region, whereas p63 expression was observed only in the basal layer. Transmission EM revealed stratified epithelium with the formation of desmosomes and hemidesmosomes. Scanning EM revealed a cobble stone-like epithelial surface without cilia formation. α-Tubulin, a major component of cilia, was expressed only in the apical region of the nasal mucosa and showed diffuse cytoplasmic staining in the CUNMEC sheets. ZO-1, a component of tight junctions, was expressed in the apical region of the nasal mucosa and was expressed at intercellular borders in CUNMECs. Conclusion Following transplantation, the CUNMEC sheet presented a stratified epithelial layer containing GCs but without cilia and expressed progenitor cell markers, which are morphologically similar to those of ocular surface epithelia and may have the potential to function as a surrogate epithelium for ocular surface reconstruction, especially in dry eye conditions.
Opening
From Preoperative Findings to Procedure Choice: A Practical Overivew of Corneal and Intraocular Refractive Surgery

萬懿 Yi WanTaiwan Speaker From Preoperative Findings to Procedure Choice: A Practical Overivew of Corneal and Intraocular Refractive SurgeryThe outcome of refractive surgery is closely tied to how well patients are evaluated before surgery. This talk will give a practical overview of how preoperative findings help guide the choice between corneal and intraocular refractive procedures, drawing on the insights from recent literature. Topics include ocular surface condition, corneal biomechanics, and optical quality. Special attention will be given to findings that may limit certain procedures, such as severe dry eye, corneal dystrophy or degeneration, significant high-order aberrations, unstable biomechanics, nystagmus, previous enhancement, systemic disease, and large angle kappa. Age, refractive range, and lifestyle factors also play a role in deciding between corneal laser surgery and intraocular options like phakic or pseudophakic IOLs. The aim is to share a clear, clinically useful approach for safer and more individualized refractive surgery planning.
Intra OP & Post OP Complication Management in Corneal Refractive Surgery

陳弘誌 Hung-Chih ChenTaiwan Speaker Intra OP & Post OP Complication Management in Corneal Refractive SurgeryCorneal refractive surgery has evolved significantly with modern laser platforms, diagnostic technologies, and surgical techniques, offering high safety, predictability, and patient satisfaction. Despite advancements, intraoperative and postoperative complications remain critical determinants of visual outcomes, warranting prompt recognition and evidence-based management. This review highlights key complication profiles and practical strategies for optimized peri-operative care in refractive procedures, including PRK, LASIK and KLEx. Intra-OP complications in corneal laser surgery primarily involve flap-related issues in LASIK (incomplete, irregular, free, or displaced flaps), docking or suction loss in femtosecond platforms, and interface problems. In KLEx, challenges include suction loss, black spots, cap perforation, retained lenticule fragments, incision tearing, and extraction difficulty. Immediate management strategies emphasize maintaining tissue integrity, minimizing further manipulation, and appropriate surgical abort or conversion when indicated. Post-OP adverse events may include dry eye disease, epithelial ingrowth, diffuse lamellar keratitis (DLK), infection, corneal haze, ectasia, residual refractive error, night vision disturbances, and elevated intraocular pressure. Management requires a tailored approach, such as aggressive lubrication and anti-inflammation support for ocular surface disease, early steroid escalation for haze and DLK, interface washout for progressive ingrowth, corneal cross-linking for biomechanical instability, and enhancement surgery when refractive targets are unmet. Regular monitoring via corneal tomography, epithelial mapping, and wavefront analysis aids early detection and intervention. A structured management algorithm, proactive risk assessment, surgeon experience, and patient-specific optimization remain essential to achieving safe, sustainable refractive outcomes and minimizing long-term morbidity.
Preoperative Tomographic and Biomechanical Corneal Assessment for Refractive Surgery

胡鴻琳 Hung-Ling HuTaiwan Speaker Preoperative Tomographic and Biomechanical Corneal Assessment for Refractive SurgerySummary Appropriate patient selection remains fundamental to safe refractive laser surgery. Corneal tomography and corneal biomechanics are central to identifying early ectatic changes and biomechanical vulnerability. Tomography offers a 3-dimensional assessment of anterior and posterior corneal surfaces, enabling detection of subtle keratoconus and other contraindications. Key parameters such as posterior elevation patterns and pachymetric distribution help quantify ectasia risk. Corneal biomechanics, assessed with technologies like the Corvis ST or ORA, provide direct measurements of tissue stability. Metrics including deformation amplitude and corneal stiffness can uncover susceptibility to postoperative ectasia, even when tomography findings are within normal limits. Integrating both modalities improves preoperative risk stratification, enhances surgical safety, and supports more individualized refractive planning.
Q&A

702