|
14:30
17:30
|
EN
-
-
林昭文 Chao-Wen LinTaiwan
Speaker
Neuroprotective Effects of Novel Treatments on Optic NeuritisOptic neuritis can cause visual impairment through retinal nerve fiber layer (RNFL) degeneration. Optical coherence tomography (OCT) could serve as a sensitive noninvasive tool for measuring RNFL thickness and evaluating the neuroprotective effects of treatment. In this topic, we reported a meta-analysis to compare RNFL loss between novel add-on treatments and traditional corticosteroid therapy after acute optic neuritis. The outcome measures were mean differences in (1) RNFL thickness compared with the baseline in the affected and unaffected eye and (2) LogMAR visual acuity (VA). Seven studies involving five novel agents (memantine, erythropoietin, interferon-beta, phenytoin, and clemastine) were included.
-
-
蔡榮坤 Rong-Kung TsaiTaiwan
Speaker
Current Potential Neuroprotectants on Optic NeuropathiesHuman optic nerve can not regenerate after optic nerve damage. Current treatments of optic neuropathies are limited by using steroids and supportive treatments. After optic nerve injury, the primary insult affect the optic nerve function immediately, the secondly damage occurs by barrier shotdown and inflammation and results in RGCs apoptosis around one to two weeks. Therefore, there may exist some neuroprotectants to prevent the second insults to protect RGCs in the therapeutic window. For optic atrophy from all causes, cell-replacement therapies may serve as an emerging regenerative medicine in the future. Several preclinical reports and clinical trials have shown some promising results in neuroprotection and neuro-regeneration. This talk will discuss some potential neuroprotectants and neuro-regeneration in current era, as well as the challenges to conduct clinical trials.
-
-
-
Satoshi KashiiJapan
Speaker
Why do we roll our eyes? The fundamentals of vision—light perception, visual acuity, and the visual field—are perceived by the brain through complex logarithmic transformations of external stimuli. This mathematical operation is performed by the axonal projections of neurons from the retina through the optic nerve to the visual cortex (V1). The complex coordinate transformations are actually the result of intermolecular forces. However, vision is not simply a static perception of images on the retina. Through the oculomotor system, the brain dynamically and predictively captures objects, reconstructing the external world within the brain while reproducing visual images. Without moving the eyes, it is impossible to perceive depth. For example, fixating on the center of a slanted pencil, cover your right eye. You will immediately notice the upper end tilted temporally. Covering the left eye induces an outward (temporal) tilt of the upper end. The perceived images of a vertical object in each eye are extorted. Here, we roll our eyes to optimize the cyclodisparity stimulus for stereoscopic depth perception in the pitch plane—that is, to see things in 3D: length, width, and “depth”. But that’s not all. Vergence eye movements are not essential for stereoscopic depth perception. We do not need to roll our eyes to see things in 3D once we have learned and developed binocular vision during the critical period of visual system development. The key to 3D vision lies in neurodevelopment during infancy.
-
-
孫銘輝 Ming-Hui SunTaiwan
Speaker
Eye movement disorders in neurodegenerative diseasesEye movement includes saccade, pursuit, and vergence. Abnormal eye movement or accuracy and speed of saccade was common in patients with neurodegeneration diseases such as Parkinson disease. Recording eye movement by using eye tracker has a diagnostic value in differentiating between these disorders and also help the existence of underlying common pathological mechanisms.
-
-
-
Umapathi N.ThirugnanamSingapore
Speaker
Do Not fear Nystagmus!Using a series of clinical cases, I would illustrate a mechanistic approach to understanding the different types of nystagmus and their clinical significance.
-
-
鄭惠禎 Hui-Chen ChengTaiwan
Speaker
Clinical Management of NystagmusNystagmus is characterized by involuntary, rapid, and repetitive eye movements that can substantially affect visual function and quality of life. Its clinical management requires a comprehensive, multidisciplinary approach that may include optical correction, pharmacologic therapy, and, in selected cases, surgical procedures to modify extraocular muscle positioning. This presentation aims to summarize the current evidence and practical strategies for managing nystagmus in daily clinical practice.
-
-
蔡榮坤 Rong-Kung TsaiTaiwan
Moderator
Current Potential Neuroprotectants on Optic NeuropathiesHuman optic nerve can not regenerate after optic nerve damage. Current treatments of optic neuropathies are limited by using steroids and supportive treatments. After optic nerve injury, the primary insult affect the optic nerve function immediately, the secondly damage occurs by barrier shotdown and inflammation and results in RGCs apoptosis around one to two weeks. Therefore, there may exist some neuroprotectants to prevent the second insults to protect RGCs in the therapeutic window. For optic atrophy from all causes, cell-replacement therapies may serve as an emerging regenerative medicine in the future. Several preclinical reports and clinical trials have shown some promising results in neuroprotection and neuro-regeneration. This talk will discuss some potential neuroprotectants and neuro-regeneration in current era, as well as the challenges to conduct clinical trials.
王安國 An-Guor WangTaiwan
Moderator
Upshooting Eye After TED IR Myectomy: How Do We Manage? Two TED patients received IR myectomy for hypotropoia. They developed upshooting eyes with severe limitation of infraduction postoperatively. We collaborated with ENT surgeon using endoscopic surgery with navigation system to identify the proximal stump of IR, and repair with non-absorbable suture. Both patients recovered their binocular vision after the operation.
鄭惠禎 Hui-Chen ChengTaiwan
Discussant
Clinical Management of NystagmusNystagmus is characterized by involuntary, rapid, and repetitive eye movements that can substantially affect visual function and quality of life. Its clinical management requires a comprehensive, multidisciplinary approach that may include optical correction, pharmacologic therapy, and, in selected cases, surgical procedures to modify extraocular muscle positioning. This presentation aims to summarize the current evidence and practical strategies for managing nystagmus in daily clinical practice.
林昭文 Chao-Wen LinTaiwan
Discussant
Neuroprotective Effects of Novel Treatments on Optic NeuritisOptic neuritis can cause visual impairment through retinal nerve fiber layer (RNFL) degeneration. Optical coherence tomography (OCT) could serve as a sensitive noninvasive tool for measuring RNFL thickness and evaluating the neuroprotective effects of treatment. In this topic, we reported a meta-analysis to compare RNFL loss between novel add-on treatments and traditional corticosteroid therapy after acute optic neuritis. The outcome measures were mean differences in (1) RNFL thickness compared with the baseline in the affected and unaffected eye and (2) LogMAR visual acuity (VA). Seven studies involving five novel agents (memantine, erythropoietin, interferon-beta, phenytoin, and clemastine) were included.
-
孫雯軒 Wen-Hsuan SunTaiwan
Speaker
A Case of Sudden Vision Loss After Cardiac SurgeryA 52-year-old woman with Marfan syndrome and a long-standing history of complex aortic disease presented with sudden blurred vision in her right eye one day after undergoing major cardiovascular surgery. She previously received a Bentall procedure with a mechanical aortic valve and had multiple episodes of progressive aortic dissection requiring repeated arch grafting and endovascular repair. Over the past several months, she had been followed by cardiovascular surgery for dizziness, nausea, intermittent visual disturbance, and episodic chest and back discomfort. Her medical history also included hypertension and chronic anticoagulation, with recent laboratory tests showing elevated PT and INR. After her most recent operation for thoracoabdominal aortic pathology, she noted acute painless visual decline. Her best-corrected visual acuity was 0.05 in the right eye and 0.5 in the left, with a right relative afferent pupillary defect. The intraocular pressure showed 8 mmHg in the right eye and 10 mmHg in the left eye. Fundus examination revealed only subtle optic pallor without disc edema or cherry-red spot. Further image studies were arranged.
-
林韋寧 Wei-Ning LinTaiwan
Speaker
Challenge CaseA challenge case will be presented.離開與回歸：我在不同醫療場域中找到的眼科價值離開醫學中心到基層，三年後又再回到醫中就職，職涯中的轉折，是機運與選擇共同譜寫出的有趣故事。
-
林德蘭 De-Lan LinTaiwan
Speaker
Bilateral blurred vision for two monthsA 66-year-old man presented with a two-month history of bilateral blurred vision. He reported difficulty seeing objects, including an inability to clearly identify vehicle license plates, along with diminished image clarity while watching television. These symptoms persisted without any improvement over the entire two-months.
-
701G
|
