Exploration of Normal Tension Glaucoma

莊蘭馨 Lan-Hsin ChuangTaiwan Speaker Exploration of Normal Tension GlaucomaNormal-tension glaucoma (NTG) presents a unique clinical challenge: progressive optic neuropathy occurs despite intraocular pressures (IOP) within the statistically normal range. This talk explores current insights into the pathophysiology, diagnosis, and management of NTG, emphasizing emerging concepts that extend beyond traditional IOP-centric models of glaucoma care. Key mechanisms—including vascular dysregulation, impaired autoregulation, systemic hypotension, and translaminar pressure gradients contributing to optic nerve susceptibility—will be reviewed. Advances in imaging and functional testing that enhance early detection, particularly structural biomarkers identified through optical coherence tomography angiography, will also be discussed. Therapeutic strategies will be outlined, including IOP-lowering interventions and modification of systemic risk factors. In addition, we will examine the evolving understanding of the relationship between high myopia and NTG. Findings from our longitudinal study suggest that increased axial length may heighten optic nerve susceptibility, further informing individualized approaches to NTG management.