Genomic Investigations on the Progression of Childhood Myopia 

彭智培 Calvin PangHong Kong, China Speaker Genomic investigations on the progression of childhood myopiaCalvin CP Pang彭智培 Department of ophthalmology and visual sciences, The Chinese University of Hong Kong, Hong Kong, China Myopia, the commonest ocular disorder in most populations estimated to affect a half of the world’s population in 2050, is prevalent and serious in East Asians with a steep rising trend in Caucasian and other Asian populations. More than 200 associated loci spreading all chromosomes are associated with myopia. While children of myopic parents across most populations are more prone to develop myopia, lifestyles in near work and outdoor time also cast strong influence. After onset of myopia, progression is different among children. In our cohorts of Chinese trio families, school children at different severities, and children receiving atropine, we conducted whole genome association studies (GWAS) and whole exome sequencing (WES) to investigate genetic loci in association with myopia progression based on quantitative traits, myopia progression over 3 years and lifestyle parameters. Based on our three stage GWAS of children myopia, there are associations of scleral equivalent and axial length with SNPs in MIR4275, LOC101928911, TENM3 and FAM135B. We calculated children’s genetic risk score (GRS) and found myopia severity increased with both near work and GRS levels, higher GRS showed a greater decrease in SE with the same amount of near work. More genomic information will be revealed as our data analysis continues.