Section 4: Challenging cases
13 Dec 2025
16:30
17:30
701G
蔡榮坤 Rong-Kung TsaiTaiwan
Moderator
Current Potential Neuroprotectants on Optic NeuropathiesHuman optic nerve can not regenerate after optic nerve damage. Current treatments of optic neuropathies are limited by using steroids and supportive treatments. After optic nerve injury, the primary insult affect the optic nerve function immediately, the secondly damage occurs by barrier shotdown and inflammation and results in RGCs apoptosis around one to two weeks. Therefore, there may exist some neuroprotectants to prevent the second insults to protect RGCs in the therapeutic window. For optic atrophy from all causes, cell-replacement therapies may serve as an emerging regenerative medicine in the future. Several preclinical reports and clinical trials have shown some promising results in neuroprotection and neuro-regeneration. This talk will discuss some potential neuroprotectants and neuro-regeneration in current era, as well as the challenges to conduct clinical trials.
王安國 An-Guor WangTaiwan
Moderator
Upshooting Eye After TED IR Myectomy: How Do We Manage? Two TED patients received IR myectomy for hypotropoia. They developed upshooting eyes with severe limitation of infraduction postoperatively. We collaborated with ENT surgeon using endoscopic surgery with navigation system to identify the proximal stump of IR, and repair with non-absorbable suture. Both patients recovered their binocular vision after the operation.
鄭惠禎 Hui-Chen ChengTaiwan
Discussant
Clinical Management of NystagmusNystagmus is characterized by involuntary, rapid, and repetitive eye movements that can substantially affect visual function and quality of life. Its clinical management requires a comprehensive, multidisciplinary approach that may include optical correction, pharmacologic therapy, and, in selected cases, surgical procedures to modify extraocular muscle positioning. This presentation aims to summarize the current evidence and practical strategies for managing nystagmus in daily clinical practice.
林昭文 Chao-Wen LinTaiwan
Discussant
Neuroprotective Effects of Novel Treatments on Optic NeuritisOptic neuritis can cause visual impairment through retinal nerve fiber layer (RNFL) degeneration. Optical coherence tomography (OCT) could serve as a sensitive noninvasive tool for measuring RNFL thickness and evaluating the neuroprotective effects of treatment. In this topic, we reported a meta-analysis to compare RNFL loss between novel add-on treatments and traditional corticosteroid therapy after acute optic neuritis. The outcome measures were mean differences in (1) RNFL thickness compared with the baseline in the affected and unaffected eye and (2) LogMAR visual acuity (VA). Seven studies involving five novel agents (memantine, erythropoietin, interferon-beta, phenytoin, and clemastine) were included.