Neuroprotective Effects of Novel Treatments on Optic Neuritis

林昭文 Chao-Wen LinTaiwan Speaker Neuroprotective Effects of Novel Treatments on Optic NeuritisOptic neuritis can cause visual impairment through retinal nerve fiber layer (RNFL) degeneration. Optical coherence tomography (OCT) could serve as a sensitive noninvasive tool for measuring RNFL thickness and evaluating the neuroprotective effects of treatment. In this topic, we reported a meta-analysis to compare RNFL loss between novel add-on treatments and traditional corticosteroid therapy after acute optic neuritis. The outcome measures were mean differences in (1) RNFL thickness compared with the baseline in the affected and unaffected eye and (2) LogMAR visual acuity (VA). Seven studies involving five novel agents (memantine, erythropoietin, interferon-beta, phenytoin, and clemastine) were included.