Current Potential Neuroprotectants on Optic Neuropathies

蔡榮坤 Rong-Kung TsaiTaiwan Speaker Current Potential Neuroprotectants on Optic NeuropathiesHuman optic nerve can not regenerate after optic nerve damage. Current treatments of optic neuropathies are limited by using steroids and supportive treatments. After optic nerve injury, the primary insult affect the optic nerve function immediately, the secondly damage occurs by barrier shotdown and inflammation and results in RGCs apoptosis around one to two weeks. Therefore, there may exist some neuroprotectants to prevent the second insults to protect RGCs in the therapeutic window. For optic atrophy from all causes, cell-replacement therapies may serve as an emerging regenerative medicine in the future. Several preclinical reports and clinical trials have shown some promising results in neuroprotection and neuro-regeneration. This talk will discuss some potential neuroprotectants and neuro-regeneration in current era, as well as the challenges to conduct clinical trials.